Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model

Abstract Cancer‐related fatigue (CRF) and stress are common symptoms in cancer patients represent early side effects of treatment which affect the life quality patients. CRF may partly depend on disruption circadian rhythm. Locomotor activity corticosterone rhythms two important outputs can be used to analyze possible function during development treatment. The present study analyzes relationship between locomotor rhythm, levels, hepatocellular carcinoma (HCC) development, radiotherapy a mouse model. HCC was induced mice by single injection diethylnitrosamine (DEN) chronic phenobarbital drinking water. Another group received only. Tumor bearing animals were divided randomly into four groups irradiated at different Zeitgeber time points. Spontaneous recorded continuously; serum levels p‐ERK immunoreaction suprachiasmatic nucleus (SCN) investigated. Phenobarbital treated showed damped less stable 24 hours rhythm as well an increase light phase, reminiscent sleep disruption. tumor level inactive phase decreased dark CRF. After irradiation, further increased disrupted. Lowest observed after irradiation phase; thus, this might best apply order minimize effects.